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A multi-type branching model with varying environment for bacterial dynamics with postantibiotic effect
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2009 (English)In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 256, no 1, 58-64 p.Article in journal (Refereed) Published
Abstract [en]

A multi-type branching process with varying environment was used to construct a pharmacokinetic/pharmacodynamic (PK/PD) model that captures the postantibiotic effect (PAE) seen in bacterial populations after exposure of antibiotics. This phenomenon of continued inhibition of bacterial growth even after removal of the antibiotic from the growth medium is of high relevance in the context of optimizing dosing regimens. The clinical implication of long PAEs lies in the interesting possibility of increasing the intervals between drug administrations. The model structure is generalizable to most types of antibiotics and is useful both as a theoretical framework for understanding the time properties of PAE and to explore optimal antibiotic dosing regimens. Data from an in vitro study with Escherichia coli exposed to different dosing regimens of cefotaxime were used to evaluate the model.

Place, publisher, year, edition, pages
2009. Vol. 256, no 1, 58-64 p.
Keyword [en]
Antibiotic resistance, Mathematical model, Penicillin binding proteins
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-98253DOI: 10.1016/j.jtbi.2008.09.023ISI: 000261706800005PubMedID: 18952106OAI: oai:DiVA.org:uu-98253DiVA: diva2:174002
Available from: 2009-02-18 Created: 2009-02-18 Last updated: 2011-06-30Bibliographically approved

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Andersson, Dan I
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