This chapter explores the ways in which research and innovation as gendered practices and experiences are precarized in academe (Murgia and Poggio, 2019). Drawing on professional biographical interviews conducted in 2017–18 with 30 women and men working in Digital Humanities, an emerging and innovative field in academe, the chapter analyzes how structural, organizational and professional-practice constraints as well as personal biographies shape the opportunities research and innovation afford individual researchers. In invoking the notion of precarization (Standing, 2011), the chapter is less concerned with the effects of the rise of short-term contracts and similar precarizing employment practices in academe (although these certainly feature) than with the structural and organizational ways in which research and innovation are simultaneously invited and disavowed in organizational structures that are not agile but instead work to reproduce the same.