Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, has since the outbreak in 2019had significant effects on public health. Historically, traditional medicine has been used to treatviral infections, including the herb Salvia miltiorrhiza. One of the biologically activecompounds in S. miltiorrhiza, salvianolic acid B, has shown to possess affinity towardnonstructural protein 16 (NSP16), which is vital for the replication and survival forcoronaviruses. The genetic coding for the methyl donor (SAM) binding pocket in NSP16 ishighly conserved, both between species and through mutations, making it an interesting target.With ChemGPS-NP salvianolic acid B was shown to be deviating in the chemical descriptorsincluded in the software from other compounds known to have affinity toward the SAMbinding pocket. However, it was shown through docking with molecular mechanics thatsalvianolic acid B with a docking score of -8,651 to be comparable, or exceeding, dockingscores of other antivirals with confirmed affinity to the target. Salvianolic acid B wassuccessfully extracted and isolated, yielding 220 mg from 251,31 grams of dry plant material.Herein, it is shown that salvianolic acid B may be a great candidate for further examination inthe battle against viral infections caused by coronaviruses, which would undoubtably be usefulfor humanity, both now and in the future.