Malaria is a parasitic disease that affects millions of people worldwide, particularly in tropical and subtropical regions. Pregnant women are at an increased risk of contracting malaria and IPTp using SP is a highly effective intervention recommended by the World Health Organization for preventing malaria and its adverse outcomes. Nigeria, has the highest malaria burden and one of the highest infant mortality rates globally, while only 17% of pregnant women received the recommended three or more doses of IPTp. For this study, data from the Nigerian Demographic Health Survey 2018 were used to assess the association between intermittent preventive treatment uptake and infant mortality in Nigeria. A number of 6572births that occurred 12 months prior to the data collection were included. The results showed that intermittent preventive treatment in pregnancy was not statistically significantly associated with infant mortality. Moreover, the prevalence of infant mortality was the highest among pregnant women who did not receive IPTp compared to those who received inadequate and adequate IPTp. Additionally, higher maternal education and iron supplementation were associated with higher odds of survival. IPTp intake was lower among women with no formal education, those who lived in rural areas and those who had no ANC visits. The findings suggest that it is an important intervention, but there are other contributing factors to its relationship with infant mortality. A multifaceted approach that addresses social determinants of health and improves access to quality healthcare is crucial to achieving better health outcomes for mothers and infants.