Background: When treating vitiligo, an autoimmune disease affecting the melanocytes, a cream containing a mineral complex has been found effective. The complex acts as an antioxidant similar to the endogen enzyme catalase and breaks down hydrogen peroxide, a reactive oxygen species (ROS). ROS does not only affect melanocytes but is also an underlying factor in irritated skin and erythema. Aim: To in vivo investigate the effect of a mineral complex on skin redness compared to its placebo and a reference cream. Further, to compare its effect on the biophysical parameters pigmentation, texture, volume, and pores. Methods: Two randomized, controlled, double-blinded trials were conducted. In the first trial the mineral complex was applied for 1 week to the forearm of 7 participants to investigate its’ preventing and calming effect on SLS-induced irritation. The second trial compared skin parameters before and after three weeks of applying two different creams to the face, one containing the mineral complex. The effect was measured through an Antera 3D scan, a visual scoring system, and by a questionnaire. Results: A prophylactic effect of the complex on surfactant-induced skin irritation was seen, although not significant. Treatment with the mineral complex after the induction gave no improvment compared to untreated or reference cream area. In the second study a significant decrease in redness was confirmed for the mineral complex cream. On the other parameters investigated, only wrinkle width was significantly decreased. Conclusions: It can be suggested that the topical application of a cream contaning the mineral complex can protect and prevent skin from becoming irritated or red. A calming and antiirritative effect was also confirmed when the product was applied to the face. Its effect on other biophysical parameters needs to be further investigated.