As of 2021 approximately 1.3 billion people are living with significant disabilities, of which 80 % reside in low- and middle-income countries. Uganda is an African country with a high rate of disability among women, who continue to experience challenges and barriers to access of essential services despite protections. Besides disability, another focus of the Ugandan government is early childhood development. Since 1999, they have introduced several education and care policy plans with varying results. As recently as 2016, 37 % of children were developmentally delayed. Recent evidence has suggested a relationship between maternal disability and early childhood development. This study utilised secondary data from the 2016 Uganda Demographic Health Survey. Disability and early childhood development data were collected via proxy reports for mothers and their youngest child aged between 36 and 59 months. Multivariable logistic regressions were performed to ascertain odds ratios and significance of delayed child development in the presence of maternal disability. Children from mothers with disability were found to experience significant delays in their literacy-numeracy and social-emotional development. Other significant risk factors included early childhood education, socioeconomic status, maternal education, and area of residence. The established relationship in this study suggests the consideration of children from mothers with disability as a vulnerable group, which may require targeted early childhood education and care interventions to facilitate holistic development.