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Potential genotoxicity of plant extracts used in Ethiopian traditional medicine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Gentox)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Gentox)
2009 (English)In: Journal of Ethnopharmacology, ISSN 0378-8741, E-ISSN 1872-7573, Vol. 122, no 1, 136-142 p.Article in journal (Refereed) Published
Abstract [en]

Aim of the study: Although traditional herbal medicines are widely used in Ethiopia, no information is available on their potential genotoxicity. In the present study, hydroalcoholic extracts of Glinus lotoides, Plumbago zeylanica, Rumex steudelii and Thymus schimperi were evaluated for their DNA damaging effects using the comet assay. Material and methods: Mouse lymphoma L5178Y cells were exposed to different concentrations of the extracts for 3 h with and without metabolic activation (S9-mix) using 4-nitroquinoline-N-oxide and benzo(a)pyrene as positive controls, and vehicles as negative controls. Results: In the absence of S9, all extracts were found to induce significant DNA damage without affecting the cell viability. T schimperi and R. steudelii were the most potent DNA-damaging extracts, and G. lotoides and P. zeylanica the least potent. The addition of S9 had different effects on the DNA damage induced by the extracts: it lowered the DNA damaging effect of P. zeylanica, did not affect the DNA damaging effect of T. schimperi, and increased the DNA damaging effects of R. steudelii and G. lotoides. Conclusion: The findings of the present study suggest that all extracts evaluated have a genotoxic potential in vitro which needs to be substantiated by further studies.

Place, publisher, year, edition, pages
2009. Vol. 122, no 1, 136-142 p.
Keyword [en]
Glinus lotoides, Plumbago zeylanica, Rumex steudelii, Thymus schimperi, DNA damage, Mouse lymphoma L5178Y cells, Comet assay
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-98647DOI: 10.1016/j.jep.2008.12.013ISI: 000264509100020OAI: oai:DiVA.org:uu-98647DiVA: diva2:200928
Available from: 2009-03-02 Created: 2009-03-02 Last updated: 2017-12-13Bibliographically approved

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Hellman, Björn

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