uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Optimal timing of surgery after preoperative chemoradiotherapy for rectal cancer
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences, Colorectal Surgery.
2009 (English)In: Nature clinical practice. Oncology, ISSN 1743-4254, Vol. 6, no 3, 128-9 p.Article in journal (Refereed) Published
Abstract [en]

The timing of surgery in rectal cancer treatment after neoadjuvant chemoradiotherapy is debated, mainly because of downsizing and repopulation of tumor cells. The retrospective analysis of prospectively collected data from a series of patients with locally advanced rectal cancer by Lim et al. has tried to evaluate whether timing of surgery after neoadjuvant chemoradiotherapy has any effect on tumor regression, sphincter preservation, local recurrence rate or overall survival. The study included 397 patients who had received chemoradiotherapy and surgery with different time intervals between the use of these modalities. No differences regarding all four parameters were found in patients with a time interval less or greater than 41 days. Some methodological reasons can be discussed, but the only way to answer the question of timing is, of course, to do a randomized trial.

Place, publisher, year, edition, pages
2009. Vol. 6, no 3, 128-9 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-98954DOI: 10.1038/ncponc1325PubMedID: 19153567OAI: oai:DiVA.org:uu-98954DiVA: diva2:201725
Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2009-03-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Colorectal Surgery
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 113 hits
ReferencesLink to record
Permanent link

Direct link