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Optimal timing of surgery after preoperative chemoradiotherapy for rectal cancer
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences, Colorectal Surgery.
2009 (English)In: Nature clinical practice. Oncology, ISSN 1743-4254, Vol. 6, no 3, 128-9 p.Article in journal (Refereed) Published
Abstract [en]

The timing of surgery in rectal cancer treatment after neoadjuvant chemoradiotherapy is debated, mainly because of downsizing and repopulation of tumor cells. The retrospective analysis of prospectively collected data from a series of patients with locally advanced rectal cancer by Lim et al. has tried to evaluate whether timing of surgery after neoadjuvant chemoradiotherapy has any effect on tumor regression, sphincter preservation, local recurrence rate or overall survival. The study included 397 patients who had received chemoradiotherapy and surgery with different time intervals between the use of these modalities. No differences regarding all four parameters were found in patients with a time interval less or greater than 41 days. Some methodological reasons can be discussed, but the only way to answer the question of timing is, of course, to do a randomized trial.

Place, publisher, year, edition, pages
2009. Vol. 6, no 3, 128-9 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-98954DOI: 10.1038/ncponc1325PubMedID: 19153567OAI: oai:DiVA.org:uu-98954DiVA: diva2:201725
Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2009-03-10Bibliographically approved

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