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Multicentre phase II trial of capecitabine and oxaliplatin in combination with radiotherapy for unresectable colorectal cancer: The CORGI-L study
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2009 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 45, no 5, 807-813 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: This study assessed radiotherapy combined with capecitabine and oxaliplatin in patients with primary, inextirpable colorectal adenocarcinoma. PATIENTS AND METHODS: Forty-nine patients entered the trial. Two cycles of XELOX (capecitabine 1000mg/m(2) bid d1-14+oxaliplatin 130mg/m(2) d1, q3w) were followed by radiotherapy (50.4Gy), combined with capecitabine 825mg/m(2) bid every radiotherapy day and oxaliplatin 60mg/m(2) once weekly. The primary end-point was objective response. RESULTS: Forty-seven patients were evaluable. Twenty-nine (62% [95% CI: 46-75%]) achieved complete or partial response. Thirty-eight (81%) went through surgery of whom 37 (97%) had an R0 resection and five (13%) had a pathological complete response. Seventy-eight percent were alive and estimated local progression rate was 11% at 2 years. The most common grade 3+ toxicity during chemoradiotherapy was diarrhoea (24%). CONCLUSIONS: XELOX-RT was feasible and showed promising efficacy when treating patients with primary inextirpable colorectal cancer, establishing high local control rate.

Place, publisher, year, edition, pages
2009. Vol. 45, no 5, 807-813 p.
Keyword [en]
Capecitabine, Colon cancer, Inextirpable, Oxaliplatin, Radiotherapy, Rectal cancer
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-98956DOI: 10.1016/j.ejca.2008.11.017ISI: 000266205900021PubMedID: 19110416OAI: oai:DiVA.org:uu-98956DiVA: diva2:201729
Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2010-07-28Bibliographically approved

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