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The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
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2008 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 582, no 27, 3811-3816 p.Article in journal (Refereed) Published
Abstract [en]

Solute carriers (SLCs) is the largest group of transporters, embracing transporters for inorganic ions, amino acids, neurotransmitters, sugars, purines and fatty acids among other substrates. We mined the finished assembly of the human genome using Hidden Markov Models (HMMs) obtaining a total of 384 unique SLC sequences. Detailed clustering and phylogenetic analysis of the entire SLC family showed that 15 of the families place into four large phylogenetic clusters with the largest containing eight SLC families, suggesting that many of the distinct families of SLCs have a common evolutionary origin. This study represents the first overall genomic roadmap of the SLCs providing large sequence sets and clarifies the phylogenetic relationships among the families of the second largest group of membrane proteins.

Place, publisher, year, edition, pages
2008. Vol. 582, no 27, 3811-3816 p.
Keyword [en]
Transporter, Membrane bound, SLC, Phylogeny, Repertoire, Orphan
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-98981DOI: 10.1016/j.febslet.2008.10.016ISI: 000261234800018PubMedID: 18948099OAI: oai:DiVA.org:uu-98981DiVA: diva2:201767
Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2017-12-13Bibliographically approved

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