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Arousal enhanced memory retention is eliminated following temporal lobe resection
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
2010 (English)In: Brain and Cognition, ISSN 0278-2626, E-ISSN 1090-2147, Vol. 73, no 3, 176-179 p.Article in journal (Refereed) Published
Abstract [en]

The amygdala, situated in the anterior medial temporal lobe (MTL), is involved in the emotional enhancement of memory. The present study evaluated whether anterior MTL-resections attenuated arousal induced memory enhancement for pictures. Also, the effect of MTL-resections on response latencies at retrieval was assessed. Thirty-one patients with unilateral MTL-resections (17 left, 14 right) together with 16 controls participated in a forced choice memory task with pictorial stimuli varying in arousal. Response latencies increased with stimulus arousal in controls but not in patients. This was paralleled by attenuated recognition memory for moderately and highly arousing pictures in MTL-resectioned patients as compared to healthy controls. However, patients and controls did not differ in memory performance for non-arousing pictures. These results suggest that the MTL is necessary for arousal induced memory enhancement.

Place, publisher, year, edition, pages
2010. Vol. 73, no 3, 176-179 p.
Keyword [en]
Amygdala, Emotion, IAPS pictures, Medial temporal lobe, Response latency
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-98986DOI: 10.1016/j.bandc.2010.04.009ISI: 000280020300004OAI: oai:DiVA.org:uu-98986DiVA: diva2:201782
Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2017-12-13Bibliographically approved
In thesis
1. The Amygdala, Arousal and Memory: From Lesions to Neuroimaging
Open this publication in new window or tab >>The Amygdala, Arousal and Memory: From Lesions to Neuroimaging
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Emotional events are better remembered than neutral events. But what are the mechanisms behind this memory enhancing effect? It seems that they depend on the arousal level at the moment we experience the event to be remembered.

The first study of the present thesis mapped the brain areas that changed their activity in a highly arousing situation in subjects with snake or spider phobia. Looking at pictures of their feared object engaged the amygdala, situated in the medial temporal lobe. This area has previously been demonstrated to be necessary for fear reactions. Here, the novel question was what other brain areas the amygdala engages when the brain is in a state of high arousal. Results suggest that the amygdala recruits other limbic and cortical areas known to be involved in motor behavior and object recognition. In contrast, when subjects watched fear-relevant but non-phobic pictures, amygdala activity was negatively correlated to the anterior cingulate cortex suggesting cortical inhibition.

The final two studies aimed at explaining the physiological brain mechanisms behind arousal enhancement of memory. In the first one, epileptic patients with medial temporal lobe resections including the amygdala were compared to healthy controls on a recognition memory task where the pictures to be remembered varied in arousal intensities. Results suggested that the anterior medial temporal lobe including the amygdala is necessary for arousal enhancement of memory because the enhancement effect was abolished in resectioned patients.

The last study related inter-individual differences in bodily arousal to amygdala-parahippocampal interaction. Results suggest that the beneficial effects of emotion on memory depend on arousal regulating mechanisms of the amygdala that in turn affects parahippocampal activity.

Collectively, results suggest that the amygdala is regulating changes in arousal states of the brain and body during distressful situations. Further, arousal in turn determines memory strength through gating amygdala influences on the parahippocampal cortex. Thus, the amygdala is a node both in a fear and a memory network and arousal influences the amygdala to prepare for action and to enhance memory. This seems evolutionary sound.

 

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2009. 53 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Social Sciences, ISSN 1652-9030 ; 48
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:uu:diva-98978 (URN)978-91-554-7447-8 (ISBN)
Public defence
2009-04-17, Sal X, Universitetshuset, Uppsala, 10:15 (English)
Opponent
Supervisors
Available from: 2009-03-27 Created: 2009-03-05 Last updated: 2010-12-09Bibliographically approved

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