The role of obstructive sleep apnea in metabolic syndrome: A population-based study in women
2011 (English)In: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 12, no 4, 329-334 p.Article in journal (Refereed) Published
Background: The aim of this study was to assess associations between obstructive sleep apnea (USA) and metabolic syndrome in a population-based sample of women.
Methods: Four hundred women aged 20-70 years underwent a full-night polysomnography, fasting blood sampling and measurement of anthropometric variables. Metabolic syndrome was defined according to the National Cholesterol Education Program (NCEP) criteria.
Results: The NCEP criteria of metabolic syndrome were fulfilled by 104 (26.0%) of the women. The frequency of metabolic syndrome increased from 10.5% in women with apnea-hypopnea-index (AHI) < 5 to 57.1% in women with AHI >= 30 (p for trend < 0.0001). In the multivariate analysis, the severity of USA measured as AHI, ODI (oxygen desaturation index), minimal saturation or T-90 (percentage of time during night with saturation < 90%) were associated with metabolic syndrome after adjustment for age, level of physical activity, smoking and alcohol consumption. AHI (adj. OR 1.45; 95% CI 1.11-1.91), ODI (1.37; 1.09-1.73) and minimal saturation level (0.93; 0.87-0.99) remained significantly associated with metabolic syndrome also when adjusting for the waist-to-hip-ratio. The three markers of USA were independently associated with central obesity, hypertriglyceridemia and reduced HDL cholesterol concentration.
Conclusion: Measures of USA were closely associated with metabolic syndrome and its components in this population-based sample of women also after adjustments. Therefore, when the health consequences of sleep-disordered breathing are investigated it is important to consider metabolic syndrome. Sleep-disordered breathing should also be considered when treating patients with metabolic syndrome.
Place, publisher, year, edition, pages
2011. Vol. 12, no 4, 329-334 p.
Obstructive sleep apnea, metabolic syndrome, women, population-based
Respiratory Medicine and Allergy
Research subject Lung Medicine
IdentifiersURN: urn:nbn:se:uu:diva-99078DOI: 10.1016/j.sleep.2010.06.014ISI: 000290080400004PubMedID: 21345723OAI: oai:DiVA.org:uu-99078DiVA: diva2:202083