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Decreased memory for novel object recognition in chronically food-restricted mice is reversed by acute ghrelin administration
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Funktionell Farmakologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Funktionell Farmakologi)
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2008 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 153, no 4, 929-34 p.Article in journal (Refereed) Published
Abstract [en]

It has been demonstrated, in normal and aged rats and mice, that acute i.c.v. ghrelin (Ghr) administration increases memory retention. In order to evaluate if this treatment, restores memory retention in animals exhibiting impaired memory, in the present work we selected a chronic food restriction mouse model (since undernutrition prejudices higher nervous functions). We employed adult female mice with 28 days of 50% food restriction and evaluated: a) behavioral performance using novel object recognition test for memory, and plus maze for anxiety-like behavior, b) some morphometric parameters as body and hepatic weights and c) plasma Ghr levels. The animals with 50% food restriction showed an increase in plasma Ghr levels and a decrease in morphometric parameters and in the percentage of novel object recognition time. When the peptide was i.c.v. injected in food-restricted animals (0.03, 0.3 or 3.0 nmol/microl), memory increases in relation to food-restricted mice injected with vehicle, reaching a performance similar to controls.

Place, publisher, year, edition, pages
2008. Vol. 153, no 4, 929-34 p.
Keyword [en]
ghrelin, memory retention, food restriction, spontaneous object recognition test, plus maze test
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-99128DOI: 10.1016/j.neuroscience.2008.03.015ISI: 000256742200005PubMedID: 18434026OAI: oai:DiVA.org:uu-99128DiVA: diva2:202254
Available from: 2009-03-09 Created: 2009-03-09 Last updated: 2017-12-13Bibliographically approved

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