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Ghrelin in the CNS: from hunger to a rewarding and memorable meal?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
2008 (English)In: Brain Research Reviews, ISSN 0165-0173, E-ISSN 1872-6321, Vol. 58, no 1, 160-170 p.Article, review/survey (Refereed) Published
Abstract [en]

Ghrelin, the endogenous agonist of the growth hormone secretagogue receptor, has been shown to induce robust feeding responses in numerous experimental models. Although ghrelin comes from both peripheral and central sources, its hyperphagic properties, to a large extent, arise from activity at the brain level. The current review focuses on describing central mechanisms through which this peptide affects consumption. We address the issue of whether ghrelin serves just as a signal of energy needs of the organism or - as suggested by the most recent findings - also affects food intake via other feeding-related mechanisms, including reward and memory. Complexity of ghrelin's role in the regulation of ingestive behavior is discussed by characterizing its influence on consumption, reward and memory as well as by defining its function within the brain circuitry and interplay with other neuropeptides.

Place, publisher, year, edition, pages
2008. Vol. 58, no 1, 160-170 p.
Keyword [en]
ghrelin, food intake, reward, energy, brain
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-99135DOI: 10.1016/j.brainresrev.2008.01.004ISI: 000257837800012PubMedID: 18308399OAI: oai:DiVA.org:uu-99135DiVA: diva2:202258
Available from: 2009-03-09 Created: 2009-03-09 Last updated: 2017-12-13Bibliographically approved

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