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Regulation of muscular contractions in the human Fallopian tube through prostaglandins and progestagens
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Dept of Woman and Child, Division for Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden.
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2008 (English)In: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 23, no 10, 2359-68 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Transport of gametes and embryos is an important function of the Fallopian tube. Both muscular contractions and cilia activity are involved in the transportation. Prostaglandins (PGs) are known mediators of muscular contractility. PG receptors have previously been demonstrated in the human Fallopian tube. The aim was to study the effect of PGs and progestagens, antiprogestin, hCG and oxytocin on muscular contractions in the human Fallopian tube, and the hormonal regulation of PG receptors. METHODS: Twenty-two healthy women operated for benign causes were included in the study. The ampullary-isthmic junction of the Fallopian tubes was excised and used for in vitro contractility studies. The effect of PGE(1), PGE(2), PGF(2alpha), progesterone, mifepristone, levonorgestrel, oxytocin and hCG on contractility was studied. Explants of Fallopian tubes were cultured for 24 h to study the effect of progestagens and hCG on the expression of PG receptors using immunohistochemistry and real-time PCR. RESULTS: Muscular contractions increased after treatment with PGF(2alpha) and PGE(2) (P < 0.05). The contractions decreased after PGE(1), progesterone, levonorgestrel, mifepristone, oxytocin and hCG (P < 0.05). In tubal explant studies, relative mRNA expression of EP1, EP2, EP3 and FP increased after levonorgestrel treatment (P < 0.05). Mifepristone and levonorgestrel treatment increased immunostaining intensity of EP1 and EP2 protein, in lumen, muscle and vessels. Progesterone and mifepristone increased immunostaining of FP in vessels. CONCLUSIONS: These data suggest that the transport of gametes and embryos involves the action of PGs, progesterone, oxytocin and hCG on muscular contractility.

Place, publisher, year, edition, pages
2008. Vol. 23, no 10, 2359-68 p.
Keyword [en]
hCG, mifepristone, progestagens, prostaglandins, tubal transport
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-99202DOI: 10.1093/humrep/den260ISI: 000259327300026PubMedID: 18621753OAI: oai:DiVA.org:uu-99202DiVA: diva2:207384
Available from: 2009-03-11 Created: 2009-03-10 Last updated: 2017-12-13Bibliographically approved

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