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Ecstasy analogues found in cacti
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
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2008 (English)In: Journal of Psychoactive Drugs, ISSN 0279-1072, E-ISSN 2159-9777, Vol. 40, no 2, 219-222 p.Article in journal (Refereed) Published
Abstract [en]

Human interest in psychoactive phenethylamines is known from the use of mescaline-containing cacti and designer drugs such as Ecstasy. From the alkaloid composition of cacti we hypothesized that substances resembling Ecstasy might occur naturally. In this article we show that lophophine, homopiperonylamine and lobivine are new minor constituents of two cactus species, Lophophora williamsii (peyote) and Trichocereus pachanoi (San Pedro). This is the first report of putatively psychoactive phenethylamines besides mescaline in these cacti. A search for further biosynthetic analogues may provide new insights into the structure-activity relationships of mescaline. An intriguing question is whether the new natural compounds can be called "designer drugs."

Place, publisher, year, edition, pages
2008. Vol. 40, no 2, 219-222 p.
Keyword [en]
ecstasy, homopiperonylamine, lophophine, lobivine, peyote, San Pedro
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-99308ISI: 000257868400015PubMedID: 18720674OAI: oai:DiVA.org:uu-99308DiVA: diva2:207536
Available from: 2009-03-11 Created: 2009-03-11 Last updated: 2017-12-13Bibliographically approved

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Bruhn, Jan G.

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