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A Poly(Lactic Acid-Co-Caprolactone)–Collagen Hybrid for Tissue Engineering Applications
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry. (polymerkemi)
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry. (polymerkemi)
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2009 (English)In: Tissue engineering Part A, ISSN 1937-3341, Vol. 15, no 7, 1667-1675 p.Article in journal (Refereed) Published
Abstract [en]

 A biodegradable hybrid scaffold consisting of a synthetic polymer,   poly(lactic acid-co-caprolactone) (PLACL), and a naturally derived   polymer, collagen, was constructed by plastic compressing hyperhydrated  collagen gels onto a flat warp-knitted PLACL mesh. The collagen   compaction process was characterized, and it was found that the duration, rather than the applied load under the test conditions in the  plastic compression, was the determining factor of the collagen and cell density in the cell-carrying component. Cells were spatially   distributed in three different setups and statically cultured for a   period of 7 days. Short-term biocompatibility of the hybrid construct   was quantitatively assessed with AlamarBlue and qualitatively with   fluorescence staining and confocal microscopy. No significant cell   death was observed after the plastic compression of the interstitial   equivalents, confirming previous reports of good cell viability   retention. The interstitial, epithelial, and composite tissue   equivalents showed no macroscopic signs of contraction and good cell   proliferation with a two- to threefold increase in cell number over 7   days. Quantitative analysis showed a homogenous cell distribution and   good biocompatibility. The results indicate that viable and proliferating multilayered tissue equivalents can be engineered using   the PLACL-collagen hybrid construct in the space of several hours.

Place, publisher, year, edition, pages
Mary Ann Liebert, Inc. , 2009. Vol. 15, no 7, 1667-1675 p.
National Category
Chemical Sciences
Research subject
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-99352DOI: 10.1089/ten.tea.2008.0194ISI: 000267843700022OAI: oai:DiVA.org:uu-99352DiVA: diva2:207710
Available from: 2009-03-12 Created: 2009-03-12 Last updated: 2010-07-19Bibliographically approved

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Publisher's full texthttp://www.liebertonline.com/doi/pdf/10.1089/ten.tea.2008.0194
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