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Cognitive function in children and subsequent type 2 diabetes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Funktionell Farmakologi)
2008 (English)In: Diabetes Care, ISSN 0149-5992, Vol. 31, no 3, 514-516 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To assess whether a diagnosis of type 2 diabetes by age 42 years is associated with prior cognitive deficits in childhood. RESEARCH DESIGN AND METHODS: Logistic regression estimated type 2 diabetes risk among 9,113 members of the 1958 British birth cohort of the National Child Development Study (NCDS). Associations with type 2 diabetes were estimated for general ability and reading comprehension assessments at age 11 years, modeled using SD units. Adjustment was for markers of early-life exposures, social and material family characteristics, sex, and disability, with further adjustment for BMI at age 7 years. RESULTS: Adjusted odds ratios (95% CIs) for type 2 diabetes (n = 69) are 0.67 (0.51-0.87) for general ability and 0.58 (0.44-0.77) for reading comprehension. Neither additional adjustment for BMI, nor limiting the definition of type 2 diabetes to onset after age 33 years altered the associations substantially. CONCLUSIONS: Impaired cognitive function may precede clinical onset of type 2 diabetes.

Place, publisher, year, edition, pages
2008. Vol. 31, no 3, 514-516 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-99564DOI: 10.2337/dc07-1399ISI: 000253801100030PubMedID: 18083794OAI: oai:DiVA.org:uu-99564DiVA: diva2:208210
Available from: 2009-03-16 Created: 2009-03-16 Last updated: 2010-01-11Bibliographically approved

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