Suzuki coupling of aryl chlorides with phenylboronic acid in water, using microwave heating with simultaneous cooling
2005 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 7, no 11, 2101-2104 p.Article in journal (Refereed) Published
We present here a methodology for the Suzuki coupling of aryl chlorides with phenylboronic acid using Pd/C as a catalyst, water as a solvent, and microwave heating. We show that simultaneous cooling in conjunction with microwave heating prolongs the lifetime of the aryl chloride substrates during the course of the reaction and, as a result, yields of the desired biaryl as well as overall recovery of material can be increased.
Place, publisher, year, edition, pages
2005. Vol. 7, no 11, 2101-2104 p.
IdentifiersURN: urn:nbn:se:uu:diva-99768DOI: 10.1021/ol0503384ISI: 000229420400006PubMedID: 15901144OAI: oai:DiVA.org:uu-99768DiVA: diva2:208724