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Esophageal cancer: current and emerging therapy modalities
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Upper Abdominal Surgery.
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2008 (English)In: Expert Review of Anticancer Therapy, ISSN 1473-7140, Vol. 8, no 9, 1433-1448 p.Article, review/survey (Refereed) Published
Abstract [en]

During the last few years, there has been a gradual increase in treatment options for patients with esophageal malignancies. Several clinical studies have been performed, covering not only radiation and chemotherapy, but also the introduction of novel biological agents into the treatment arsenal. Patients with esophageal carcinoma are now offered second-line and sometimes even third-line treatments, and the number of research protocols is increasing. Despite the newly awakened interest in this malignancy, the overall 5-year survival rate has remained at approximately 10% since the 1980s. This review contains a compilation of available studies of esophageal malignancies and discusses current treatment options as well as newly developed therapies targeted at growth factor receptors.

Place, publisher, year, edition, pages
2008. Vol. 8, no 9, 1433-1448 p.
Keyword [en]
Chemotherapy, Epidermal growth factor, Esophageal cancer, Growth factor, Radiation, Receptor, Surgery, Vascular endothelial growth factor
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-100039DOI: 10.1586/14737140.8.9.1433ISI: 000259333300014PubMedID: 18759695OAI: oai:DiVA.org:uu-100039DiVA: diva2:209288
Available from: 2009-03-24 Created: 2009-03-24 Last updated: 2011-01-12Bibliographically approved

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