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Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
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2008 (English)In: Connective Tissue Research, ISSN 0300-8207, E-ISSN 1607-8438, Vol. 49, no 3 & 4, 215-218 p.Article in journal (Refereed) Published
Abstract [en]

Hyaluronan is an apparently simple polysaccharide that is responsible for tissue hydration but also stimulates cell proliferation, migration, and differentiation via binding to cell surface receptors, such as CD44. The amounts of hyaluronan increase during inflammation and tumorigenesis through the action of chemokines and growth factors. This review discusses some of the evidence that hyaluronan-CD44 complexes trigger signaling cascades that modulate inflammation and tumor progression.

Place, publisher, year, edition, pages
2008. Vol. 49, no 3 & 4, 215-218 p.
Keyword [en]
Hyaluronan, CD44, growth factors, stromal microenviroment, chemokines
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-100047DOI: 10.1080/03008200802143323ISI: 000258000500024PubMedID: 18661346OAI: oai:DiVA.org:uu-100047DiVA: diva2:209310
Available from: 2009-03-24 Created: 2009-03-24 Last updated: 2017-12-13Bibliographically approved

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