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Cervical metastasis from Spitz nevus of the buccal mucosa
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery. (Oral & maxillofacial surgery)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
2008 (English)In: Melanoma research, ISSN 0960-8931, E-ISSN 1473-5636, Vol. 18, no 1, 36-39 p.Article in journal (Refereed) Published
Abstract [en]

A 23-year-old woman was presented with a prolonged history of a small lump in the buccal mucosa. A local excision was performed. The morphology diagnosed a Spitz nevus and she underwent supplementary excision of scar tissue. Two years later a submandibular lump appeared on the ipsilateral side of the neck. Cytology from fine needle aspiration indicated spread of a melanocytic tumor and she underwent a modified supraomohyiod neck dissection. One of the lymph nodes showed an inclusion of cells in the deep layers with epitheloid and spindle cells in a pattern similar to that of the primary oral lesion. The finding suggests a mechanical spread of melanocytes from the Spitz nevus to the regional lymph node. After more than 3 years of follow-up there is no further manifestation of disease. It is believed that this may be an example of how a Spitz tumor, although inherently benign, can spread along lymphatics in a pseudometastatic fashion. To our knowledge this is the first report of an oral Spitz melanoma with metastatic behavior.

Place, publisher, year, edition, pages
2008. Vol. 18, no 1, 36-39 p.
Keyword [en]
juvenile melanoma, melanocytes, metastasis, spindle cell nevus, Spitz nevus
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-100477DOI: 10.1097/CMR.0b013e3282f356e4ISI: 000253463000006PubMedID: 18227706OAI: oai:DiVA.org:uu-100477DiVA: diva2:210325
Available from: 2009-04-01 Created: 2009-04-01 Last updated: 2010-06-10Bibliographically approved

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