uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Anti-collagen type II antibodies in patients with very early synovitis
MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology. (Autoimmunity)
MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham.
MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham.
Show others and affiliations
2008 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 67, no 9, 1354-1355 p.Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
2008. Vol. 67, no 9, 1354-1355 p.
Keyword [en]
Rheumatoid Arthritis (RA), Synovitis, Type II collagen (CII), Type II collagen antibody (anti-CII), anti-CCP
National Category
Immunology in the medical area
Research subject
Clinical Immunology
Identifiers
URN: urn:nbn:se:uu:diva-100476DOI: 10.1136/ard.2007.084277ISI: 000258395700032PubMedID: 18697783OAI: oai:DiVA.org:uu-100476DiVA: diva2:210347
Available from: 2009-04-01 Created: 2009-04-01 Last updated: 2018-01-13Bibliographically approved
In thesis
1. Anti-Collagen Type II Autoantibodies in an Acute Phenotype of Early Rheumatoid Arthritis
Open this publication in new window or tab >>Anti-Collagen Type II Autoantibodies in an Acute Phenotype of Early Rheumatoid Arthritis
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory features that primarily affects small peripheral joints. Type II collagen (CII), is the most abundant collagen type in joint cartilage. Antibodies against CII (anti-CII) are found in a subpopulation of RA patients. Anti-CII can form surface-bound immune complexes (IC) in inflamed joints, which might intensify joint inflammation and destruction. In this thesis I have studied the functional effects of surface-bound anti-CII–containing IC in vitro and correlated the results to clinical parameters.

Anti-CII IC induced TNF-α, IL-1β and IL-8 production from monocytes via FcγRIIa. Anti-CII levels were dichotomously distributed in RA patients where a small outlier group (3.3%) with very high anti-CII levels showed in vitro induction of pro-inflammatory cytokines by anti-CII-containing IC. These patients also had a distinct phenotype with elevated laboratory signs of inflammation and increased radiological erosions at the time of diagnosis.

In another in vitro model, co-cultured macrophages and RA synovial fibroblasts stimulated with anti-CII IC induced the production of matrix metalloproteinases (MMP)-1 and MMP-8, enzymes responsible for the initial cleavage of CII during cartilage degradation. This was mediated via production of TNF-α and IL-1β, and especially anti-CII IC-induced IL-1β sup-ported the production of MMP-1. The presence of anti-CII antibodies in patients with early synovitis was not predictive for future RA development.

In summary, I have shown how anti-CII-containing IC may explain part of the early pathogenesis and can define a distinct clinical phenotype in RA patients with high levels of anti-CII.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2009. 74 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 444
National Category
Immunology in the medical area
Research subject
Clinical Immunology
Identifiers
urn:nbn:se:uu:diva-100483 (URN)978-91-554-7486-7 (ISBN)
Public defence
2009-05-13, Rudbecksalen, Rudbeck Laboratory, Dag Hammarskjöldsv. 20, Uppsala, 09:15 (English)
Opponent
Supervisors
Available from: 2009-04-22 Created: 2009-04-01 Last updated: 2018-01-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://ard.bmj.com/cgi/content/full/67/9/1354-a

Authority records BETA

Rönnelid, Johan

Search in DiVA

By author/editor
Rönnelid, Johan
By organisation
Clinical Immunology
In the same journal
Annals of the Rheumatic Diseases
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 728 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf