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Resistin increases islet blood flow and decreases subcutaneous adipose tissue blood flow in anaesthetized rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2009 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 195, no 2, 283-288 p.Article in journal (Refereed) Published
Abstract [en]

AIM: Resistin is an adipokine which has been suggested to participate in the induction of insulin resistance associated with type 2 diabetes. The aim of the present study was to investigate whether acute administration of resistin influences tissue blood perfusion in rats. METHODS: Resistin was administered as an intravenous infusion of 7.5 microg h(-1) (1.5 mL h(-1)) for 30 min to rats anaesthetized with thiobutabarbital. A microsphere technique was used to estimate the blood flow to six different depots of white adipose tissue (WAT), brown adipose tissue (BAT), as well as to the pancreas, islets, duodenum, colon, kidneys, adrenal glands and liver. RESULTS: Resistin administration led to an increased blood flow to the pancreas and islets and a decrease in subcutaneous WAT and BAT. Intra-abdominal white adipose tissue blood flow and that to other organs were not affected. CONCLUSION: Acute administration of resistin markedly affects the blood perfusion of both the pancreas and subcutaneous white adipose tissue depots. At present it is unknown whether resistin exerts a direct effect on the vasculature, or works through local or systemic activation of endothelial cells and/or macrophages. The extent to which this might contribute to the insulin resistance caused by resistin is yet unknown.

Place, publisher, year, edition, pages
2009. Vol. 195, no 2, 283-288 p.
Keyword [en]
microsphere, pancreatic islets, white adipose tissue
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-100554DOI: 10.1111/j.1748-1716.2008.01891.xISI: 000262222700008PubMedID: 18715288OAI: oai:DiVA.org:uu-100554DiVA: diva2:210520
Available from: 2009-04-02 Created: 2009-04-02 Last updated: 2010-08-04Bibliographically approved

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