Highly Selective Iridium-Catalyzed Asymmetric Hydrogenation of Trifluoromethyl Olefins: A New Route to Trifluoromethyl-Bearing Stereocenters
2009 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 351, no 3, 375-378 p.Article in journal (Refereed) Published
Fluorine-containing compounds are useful in many applications ranging from pharmaceuticals to ferroelectric crystals. We have developed a new, highly enantioselective synthetic route to trifluoromethyl-bearing stereocenters in up to 96% ee via asymmetric hydrogenation using N,P-ligated iridium catalysts. We also hydrogenated an isomeric mixture of olefins; this reaction gave the hydrogenation product highly enantioselectively (87% ee), and only the E isomer was present after the reaction had reached 56% conversion.
Place, publisher, year, edition, pages
2009. Vol. 351, no 3, 375-378 p.
asymmetric catalysis, fluorine, hydrogenation, iridium, P-N ligands
Research subject Analytical Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-100634DOI: 10.1002/adsc.200800645ISI: 000264058900016OAI: oai:DiVA.org:uu-100634DiVA: diva2:210718