Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt.
2007 (English)In: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, Vol. 21, no 10, 857-866 p.Article in journal (Refereed) Published
Three phenolic compounds cosmosiin, caffeic acid, and p-coumaric acid were isolated for the first time from the leaves of Cupressus sempervirens L., together with cupressuflavone, amentoflavone, rutin, quercitrin, quercetin, myricitrin. The isolated compounds were identified using (1)H- and (13)C-NMR spectra. The hepatoprotective activity of the MeOH extract was carried out in liver homogenate of normal and CCl(4)-treated rats; a significant decrease in glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, cholesterol level, and triglycerides, while a significant increase in the total protein level, was observed after the oral administration of MeOH extract. The free radical scavenging activity against stable 2,2-diphenyl-2-picrylhydrazyl (DPPH*) was measured for MeOH extract and some of the isolated phenolic compounds in comparison with alpha-tocopherol and butylated hydroxy toluene as standard antioxidants using ESR technique, showed high antioxidant activity for quercetin, rutin, caffeic acid, and p-coumaric acid.
Place, publisher, year, edition, pages
2007. Vol. 21, no 10, 857-866 p.
Cupressus sempervirens L, Cupressaceae, Phenolic compounds, Hepatoprotective and Antioxidant activities
IdentifiersURN: urn:nbn:se:uu:diva-102020DOI: 10.1080/14786410601132477PubMedID: 17680494OAI: oai:DiVA.org:uu-102020DiVA: diva2:213864