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Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
2007 (English)In: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, Vol. 21, no 10, 857-866 p.Article in journal (Refereed) Published
Abstract [en]

Three phenolic compounds cosmosiin, caffeic acid, and p-coumaric acid were isolated for the first time from the leaves of Cupressus sempervirens L., together with cupressuflavone, amentoflavone, rutin, quercitrin, quercetin, myricitrin. The isolated compounds were identified using (1)H- and (13)C-NMR spectra. The hepatoprotective activity of the MeOH extract was carried out in liver homogenate of normal and CCl(4)-treated rats; a significant decrease in glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, cholesterol level, and triglycerides, while a significant increase in the total protein level, was observed after the oral administration of MeOH extract. The free radical scavenging activity against stable 2,2-diphenyl-2-picrylhydrazyl (DPPH*) was measured for MeOH extract and some of the isolated phenolic compounds in comparison with alpha-tocopherol and butylated hydroxy toluene as standard antioxidants using ESR technique, showed high antioxidant activity for quercetin, rutin, caffeic acid, and p-coumaric acid.

Place, publisher, year, edition, pages
2007. Vol. 21, no 10, 857-866 p.
Keyword [en]
Cupressus sempervirens L, Cupressaceae, Phenolic compounds, Hepatoprotective and Antioxidant activities
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-102020DOI: 10.1080/14786410601132477PubMedID: 17680494OAI: oai:DiVA.org:uu-102020DiVA: diva2:213864
Available from: 2009-04-29 Created: 2009-04-29 Last updated: 2010-03-31Bibliographically approved

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