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Antimicrobial arylcoumarins from Asphodelus microcarpus
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
2007 (English)In: Journal of natural products (Print), ISSN 0163-3864, E-ISSN 1520-6025, Vol. 70, no 1, 118-120 p.Article in journal (Refereed) Published
Abstract [en]

A new aryl coumarin glucoside, asphodelin A 4'-O-beta-d-glucoside (1), and its aglycon, asphodelin A (2), were isolated from Asphodelus microcarpus. The structures were determined by detailed spectroscopic analysis and chemical transformation as 3-(2'-hydroxy-p-O-beta-d-glucopyranosyloxyphenyl)-4,7-dihydroxy-2H-1-benzopyran-2-one (1) and 3-(2',4'-dihydroxyphenyl)-4,7-dihydroxy-2H-1-benzopyran-2-one (2), respectively. These compounds were isolated following bioactivity-directed fractionation, using antimicrobial activity, in which 1 and 2 exhibited moderate and potent activities, respectively. This is the first report of a 3-arylcoumarin derivative, a rare class of isoflavonoids, from a plant in the family Liliaceae.

Place, publisher, year, edition, pages
2007. Vol. 70, no 1, 118-120 p.
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-102022DOI: 10.1021/np060444uISI: 000243734900024PubMedID: 17253862OAI: oai:DiVA.org:uu-102022DiVA: diva2:213866
Available from: 2009-04-29 Created: 2009-04-29 Last updated: 2011-02-18Bibliographically approved

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