Aryl ketones from Acronychia pedunculata with cyclooxygenase-2 inhibitory effects
2005 (English)In: Chemistry & biodiversity, ISSN 1612-1872, Vol. 2, no 4, 463-469 p.Article in journal (Refereed) Published
1-[2,4-Dihydroxy-6-methoxy-3,5-bis(3-methylbut-2-en-1-yl)phenyl]ethanone (1), and a new aryl ketone, named acrovestenol (2), were isolated as cyclooxygenase-2 (COX-2) inhibitory principles from a CH2Cl2 extract of the bark of Acronychia pedunculata by a bioassay-guided fractionation procedure. Compound 2 inhibited COX-2 with an IC50 value of 142.0+/-2.15 microM, compared to the COX-2 inhibitory reference compound NS-398 with an IC50 value of 11.3+/-1.12 microM. Compound 1 inhibited COX-2-catalyzed PG biosynthesis with 68% at a concentration of 500 microM. The structures were determined by UV, IR, and 1D- and 2D-NMR, including TOCSY, HSQC-DEPT, and HMBC, and MS investigations.
Place, publisher, year, edition, pages
2005. Vol. 2, no 4, 463-469 p.
Natural Sciences Pharmaceutical Sciences
IdentifiersURN: urn:nbn:se:uu:diva-102038DOI: 10.1002/cbdv.200590026ISI: 000228770000004PubMedID: 17191994OAI: oai:DiVA.org:uu-102038DiVA: diva2:213880