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Antimicrobial triterpenes from Poulsenia armata Miq. Standl.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
2005 (English)In: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, Vol. 19, no 2, 197-202 p.Article in journal (Refereed) Published
Abstract [en]

Crude petroleum ether extract from the bark of Poulsenia armata showed antimicrobial activity. Activity-guided fractionation led to the isolation and structure elucidation of two active new triterpene derivatives, the stearate of glut-5-en-3beta-ol (1) and 3beta,28-diacetoxyurs-12-ene (4), for the first time as naturally occurring compounds. Compound 4 has previously been synthesized. The structures were determined by 1D- and 2D-NMR spectroscopy, mass spectrometry and chemical transformations. This is the first report on the chemistry and pharmacology of the genus.

Place, publisher, year, edition, pages
2005. Vol. 19, no 2, 197-202 p.
Keyword [en]
Poulsenia arinata, Moraceae, triterpenes, antimicrobial activity, accelerating gradient, chromatography, NMR and NIS spectrometry
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-102050DOI: 10.1080/14786410410001730724ISI: 000226668800016PubMedID: 15715266OAI: oai:DiVA.org:uu-102050DiVA: diva2:213886
Available from: 2009-04-29 Created: 2009-04-29 Last updated: 2010-10-04Bibliographically approved

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