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Tyrosine kinase signalling in embryonic stem cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (Cecilia Annerén)
2008 (English)In: Clinical Science, ISSN 0143-5221, E-ISSN 1470-8736, Vol. 115, no 1-2, 43-55 p.Article, review/survey (Refereed) Published
Abstract [en]

Pluripotent ES (embryonic stem) cells can be expanded in culture and induced to differentiate into a wide range of cell types. Self-renewal of ES cells involves proliferation with concomitant suppression of differentiation. Some critical and conserved pathways regulating self-renewal in both human and mouse ES cells have been identified, but there is also evidence suggesting significant species differences. Cytoplasmic and receptor tyrosine kinases play important roles in proliferation, survival, self-renewal and differentiation in stem, progenitor and adult cells. The present review focuses on the role of tyrosine kinase signalling for maintenance of the undifferentiated state, proliferation, survival and early differentiation of ES cells.

Place, publisher, year, edition, pages
2008. Vol. 115, no 1-2, 43-55 p.
Keyword [en]
embryonic stem cells, tyrosine kinase, self-renewal
National Category
Cell and Molecular Biology
Research subject
Cell Research
Identifiers
URN: urn:nbn:se:uu:diva-102157DOI: 10.1042/CS20070388ISI: 000257483100005PubMedID: 18547167OAI: oai:DiVA.org:uu-102157DiVA: diva2:214500
Available from: 2009-05-05 Created: 2009-05-05 Last updated: 2011-01-13Bibliographically approved

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