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Autoimmune and inflammatory disorders and risk of malignant lymphomas: an update
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
2008 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 264, no 6, 514-527 p.Article, review/survey (Refereed) Published
Abstract [en]

As specific autoimmune disorders now constitute established risk factors for malignant lymphomas, we describe this association.

We review reported risk levels, risk determinants, lymphoma subtypes and biological mechanisms in autoimmunity/inflammation, emphasizing on recent findings.

Whilst numerous reports describe average lymphoma risks in large patient groups, there's a recent shift of focus to risk determinants and the role of inflammatory activity. Studies highlight associations with diffuse large B-cell lymphoma, apart from lymphoma development in target organs of inflammation.

Future studies of high-risk patient subsets using detailed assessments of autoimmunity/inflammation and lymphoma may give important clues to lymphomagenesis.

Place, publisher, year, edition, pages
2008. Vol. 264, no 6, 514-527 p.
Keyword [en]
Autoimmunity, Chronic inflammation, Immune stimulation, Malignant lymphoma
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-102204DOI: 10.1111/j.1365-2796.2008.02029.xISI: 000260823800003PubMedID: 19017176OAI: oai:DiVA.org:uu-102204DiVA: diva2:214514
Available from: 2009-05-05 Created: 2009-05-05 Last updated: 2017-12-13Bibliographically approved

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Baecklund, Eva

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