Autoimmune and inflammatory disorders and risk of malignant lymphomas: an update
2008 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 264, no 6, 514-527 p.Article, review/survey (Refereed) Published
As specific autoimmune disorders now constitute established risk factors for malignant lymphomas, we describe this association.
We review reported risk levels, risk determinants, lymphoma subtypes and biological mechanisms in autoimmunity/inflammation, emphasizing on recent findings.
Whilst numerous reports describe average lymphoma risks in large patient groups, there's a recent shift of focus to risk determinants and the role of inflammatory activity. Studies highlight associations with diffuse large B-cell lymphoma, apart from lymphoma development in target organs of inflammation.
Future studies of high-risk patient subsets using detailed assessments of autoimmunity/inflammation and lymphoma may give important clues to lymphomagenesis.
Place, publisher, year, edition, pages
2008. Vol. 264, no 6, 514-527 p.
Autoimmunity, Chronic inflammation, Immune stimulation, Malignant lymphoma
IdentifiersURN: urn:nbn:se:uu:diva-102204DOI: 10.1111/j.1365-2796.2008.02029.xISI: 000260823800003PubMedID: 19017176OAI: oai:DiVA.org:uu-102204DiVA: diva2:214514