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Pref-1 and adipokine expression inadipose tissues of GK And Zucker rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2009 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, E-ISSN 1872-8057, Vol. 299, no 2, 163-171 p.Article in journal (Refereed) Published
Abstract [en]

In view of the central role of preadipocyte factor-1, adiponectin and leptin in white adipose tissue function, the aim of the present study was to analyze the mRNA expression of these proteins and of the inflammatory markers interleukin-6 and tumor necrosis factor-α in visceral and subcutaneous fat pads of rats with different metabolic disorders.

We demonstrated highly divergent expression of preadipocyte factor-1, upregulated expression of adiponectin, interleukin-6 and TNF-α mRNA in adipose tissues of the diabetic Goto Kakizaki rat compared to the obese Zucker rat. This was correlated to an increased number of large adipocytes and serum levels of adiponectin. Furthermore, in all four strains studied (as above plus Wistar Furth and Zucker Lean), significant heterogeneity was evident in adipokine expression within specific adipose tissues previously defined as belonging to the visceral or subcutaneous fat depots.

These results suggest that significantly increased levels of inflammation and redistribution of adipocyte size are mechanisms contributing to the development of type 2 diabetes in the GK rat.

Place, publisher, year, edition, pages
2009. Vol. 299, no 2, 163-171 p.
Keyword [en]
Adipokines, Adipocytes, Fat, Diabetes, Pref-1, Goto Kakizaki, Zucker
National Category
Endocrinology and Diabetes
Research subject
Medical Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-102205DOI: 10.1016/j.mce.2008.11.019ISI: 000263662500004OAI: oai:DiVA.org:uu-102205DiVA: diva2:214517
Available from: 2009-05-05 Created: 2009-05-05 Last updated: 2011-11-02Bibliographically approved

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Barbu, AndreeaPersdotter Hedlund, GabriellaCarlsson, Carina

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