uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Regulation of the beta cell mass by hormones and growth factors
Show others and affiliations
2001 (English)In: Diabetes, ISSN 0012-1797, Vol. 50, no Suppl . 1, 25-29 p.Article in journal (Refereed) Published
Abstract [en]

Substantial new information has accumulated on molecular mechanisms of pancreas development, regulation of beta-cell gene expression, and the role of growth factors in the differentiation, growth, and regeneration of beta-cells. The present review focuses on some recent studies on the mechanism of action of cytokines such as growth hormone (GH) and prolactin (PRL) in beta-cell proliferation and gene expression-in particular, the role of signal transducers and activators of transcription (STAT) proteins. The implication of the discovery of suppressors of cytokine signaling (SOCS) proteins for the interaction between stimulatory and inhibitory cytokines, including GH, PRL, leptin, and the proinflammatory cytokines interleukin-1 and interferon-gamma, in beta-cell survival is not yet clear. Recent studies indicate a role of cell adhesion molecules and the delta-like protein preadipocyte factor 1/fetal antigen 1 (Pref-1/FA-1) in cytokine-induced beta-cell growth and development. Surprisingly, glucagon-like peptide-1 (GLP-1) was recently found to stimulate not only insulin secretion but also beta-cell replication and differentiation, which may present a new perspective in treatment of type 2 diabetes. Together with the intriguing reports on positive effects of insulin on both beta-cell growth and function, a picture is emerging of an integrated network of signaling events acting in concert to control beta-cell mass adaptation to insulin demand.

Place, publisher, year, edition, pages
2001. Vol. 50, no Suppl . 1, 25-29 p.
National Category
Medical and Health Sciences
Research subject
Medical Cell Biology
URN: urn:nbn:se:uu:diva-102215PubMedID: 11272193OAI: oai:DiVA.org:uu-102215DiVA: diva2:214522
Available from: 2009-05-05 Created: 2009-05-05 Last updated: 2009-10-06Bibliographically approved

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Carlsson, Carina
By organisation
Department of Medical Cell Biology
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 194 hits
ReferencesLink to record
Permanent link

Direct link