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Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Cancer Pharmacology and Informatics)
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2008 (English)In: Genome biology, ISSN 1465-6914, Vol. 9, no 9, R136- p.Article in journal (Refereed) Published
Abstract [en]

We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series of a tumor cell line mixed with its paired normal cell line and data generated on Affymetrix and Illumina platforms, including paired tumor-normal samples and tumors characterized by fluorescent in situ hybridization, we demonstrate a high sensitivity and specificity of the strategy for detecting both minute and gross allelic imbalances in heterogeneous tumor samples.

Place, publisher, year, edition, pages
2008. Vol. 9, no 9, R136- p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-102223DOI: 10.1186/gb-2008-9-9-r136ISI: 000260586900014PubMedID: 18796136OAI: oai:DiVA.org:uu-102223DiVA: diva2:214534
Available from: 2009-05-06 Created: 2009-05-06 Last updated: 2010-05-07Bibliographically approved

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Isaksson, AndersRosenquist, Richard
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Department of Medical SciencesDepartment of Genetics and Pathology
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