Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays.
2008 (English)In: Genome biology, ISSN 1465-6914, Vol. 9, no 9, R136- p.Article in journal (Refereed) Published
We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series of a tumor cell line mixed with its paired normal cell line and data generated on Affymetrix and Illumina platforms, including paired tumor-normal samples and tumors characterized by fluorescent in situ hybridization, we demonstrate a high sensitivity and specificity of the strategy for detecting both minute and gross allelic imbalances in heterogeneous tumor samples.
Place, publisher, year, edition, pages
2008. Vol. 9, no 9, R136- p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-102223DOI: 10.1186/gb-2008-9-9-r136ISI: 000260586900014PubMedID: 18796136OAI: oai:DiVA.org:uu-102223DiVA: diva2:214534