A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
2008 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 40, no 2, 152-154 p.Article in journal (Refereed) Published
We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 x 10(-17), odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development.
Place, publisher, year, edition, pages
2008. Vol. 40, no 2, 152-154 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-102294DOI: 10.1038/ng.71ISI: 000252732900011PubMedID: 18204448OAI: oai:DiVA.org:uu-102294DiVA: diva2:214606