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A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
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2008 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 40, no 2, 152-154 p.Article in journal (Refereed) Published
Abstract [en]

We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 x 10(-17), odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development.

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2008. Vol. 40, no 2, 152-154 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-102294DOI: 10.1038/ng.71ISI: 000252732900011PubMedID: 18204448OAI: oai:DiVA.org:uu-102294DiVA: diva2:214606
Available from: 2009-05-06 Created: 2009-05-06 Last updated: 2017-12-13Bibliographically approved

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Alarcón-Riquelme, Marta E.

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