uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus
Show others and affiliations
2008 (English)In: Genes and Immunity, ISSN 1466-4879, E-ISSN 1476-5470, Vol. 9, no 4, 389-393 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies have demonstrated that in admixed populations, West African ancestry is associated with an increased prevalence of systemic lupus erythematosus (SLE). In the current study, the effect of Amerindian ancestry in SLE was examined in an admixed population in Argentina. The Argentine population is predominantly European with approximately 20% Amerindian admixture, and a very small (<2%) contribution from West Africa. The results indicate that Amerindian admixture in this population is associated with a substantial increase in SLE susceptibility risk (Odds Ratio=7.94, P=0.00006). This difference was not due to known demographic factors, including site of collection, age and gender. In addition, there were trends towards significance for Amerindian ancestry influencing renal disease, age of onset and anti-SSA antibodies. These studies suggest that populations with Amerindian admixture, like those with West African admixture, should be considered in future studies to identify additional allelic variants that predispose to SLE.

Place, publisher, year, edition, pages
2008. Vol. 9, no 4, 389-393 p.
Keyword [en]
admixture, systemic lupus erythematosus, autoimmunity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-102302DOI: 10.1038/gene.2008.25ISI: 000256388500016PubMedID: 18401351OAI: oai:DiVA.org:uu-102302DiVA: diva2:214615
Available from: 2009-05-06 Created: 2009-05-06 Last updated: 2017-12-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Alarcon-Riquelme, Marta E.

Search in DiVA

By author/editor
Alarcon-Riquelme, Marta E.
By organisation
Department of Genetics and Pathology
In the same journal
Genes and Immunity
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 398 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf