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Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. (Reumatologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2008 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 141, no 1, 69-72 p.Article in journal (Refereed) Published
Abstract [en]

Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.

Place, publisher, year, edition, pages
2008. Vol. 141, no 1, 69-72 p.
Keyword [en]
human germinal-centre-associated protein, lymphoma, rheumatoid arthritis, diffuse large B-cell lymphoma, B-cells
National Category
Clinical Medicine
URN: urn:nbn:se:uu:diva-102396DOI: 10.1111/j.1365-2141.2008.07011.xISI: 000253757400008PubMedID: 18324968OAI: oai:DiVA.org:uu-102396DiVA: diva2:216083
Available from: 2009-05-06 Created: 2009-05-06 Last updated: 2014-08-13Bibliographically approved

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Baecklund, EvaBacklin, CarinEnblad, GunillaSundström, ChristerRosenquist, Richard
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RheumatologyDepartment of Genetics and PathologyDepartment of Oncology, Radiology and Clinical ImmunologyOncology
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British Journal of Haematology
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