Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis
2008 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 141, no 1, 69-72 p.Article in journal (Refereed) Published
Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.
Place, publisher, year, edition, pages
2008. Vol. 141, no 1, 69-72 p.
human germinal-centre-associated protein, lymphoma, rheumatoid arthritis, diffuse large B-cell lymphoma, B-cells
IdentifiersURN: urn:nbn:se:uu:diva-102396DOI: 10.1111/j.1365-2141.2008.07011.xISI: 000253757400008PubMedID: 18324968OAI: oai:DiVA.org:uu-102396DiVA: diva2:216083