Effects of proinsulin C-peptide on oxygen transport, uptake and utilization in insulinopenic diabetic subjects: a review
2009 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, Vol. 645, 193-198 p.Article in journal (Refereed) Published
Exogenous C-peptide administration has beneficial effects in many of the tissues commonly affected by diabetic complications. Diabetes-induced circulatory impairments such as decreased blood flow are prevented by C-peptide, possibly via Ca2+-mediated effects on nitric oxide release. C-peptide also improves diabetes-induced erythrocyte deformability, which likely improves oxygen availability and uptake in affected tissues. Furthermore, C-peptide prevents diabetic neuropathy via improvements of endoneural blood flow and by preventing axonal swelling. In the kidney, C-peptide normalizes the diabetes-induced increase in oxygen consumption via inhibition of the Na+/K+-ATPase. Surprisingly, C-peptide has also been shown to prevent complications in patients with type II diabetes. Taken together, these results may indicate that C-peptide treatment has the potential to reduce the prevalence of diabetic complications. In this paper, the current knowledge regarding these beneficial effects of C-peptide administered to diabetic subjects will be reviewed briefly.
Place, publisher, year, edition, pages
New York: Springer US , 2009. Vol. 645, 193-198 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-102381DOI: 10.1007/978-0-387-85998-9_30ISI: 000262627100030PubMedID: 19227471ISBN: 978-0-387-85997-2ISBN: 978-0-387-85998-9OAI: oai:DiVA.org:uu-102381DiVA: diva2:216086
Annual Conference of the International-Society-on-Oxygen-Transport-to-Tissue