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Effects of proinsulin C-peptide on oxygen transport, uptake and utilization in insulinopenic diabetic subjects: a review
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi. (Nordquist)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
2009 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 645, 193-198 p.Article in journal (Refereed) Published
Abstract [en]

Exogenous C-peptide administration has beneficial effects in many of the tissues commonly affected by diabetic complications. Diabetes-induced circulatory impairments such as decreased blood flow are prevented by C-peptide, possibly via Ca2+-mediated effects on nitric oxide release. C-peptide also improves diabetes-induced erythrocyte deformability, which likely improves oxygen availability and uptake in affected tissues. Furthermore, C-peptide prevents diabetic neuropathy via improvements of endoneural blood flow and by preventing axonal swelling. In the kidney, C-peptide normalizes the diabetes-induced increase in oxygen consumption via inhibition of the Na+/K+-ATPase. Surprisingly, C-peptide has also been shown to prevent complications in patients with type II diabetes. Taken together, these results may indicate that C-peptide treatment has the potential to reduce the prevalence of diabetic complications. In this paper, the current knowledge regarding these beneficial effects of C-peptide administered to diabetic subjects will be reviewed briefly.

Place, publisher, year, edition, pages
New York: Springer US , 2009. Vol. 645, 193-198 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-102381DOI: 10.1007/978-0-387-85998-9_30ISI: 000262627100030PubMedID: 19227471ISBN: 978-0-387-85997-2 (print)ISBN: 978-0-387-85998-9 (print)OAI: oai:DiVA.org:uu-102381DiVA: diva2:216086
Conference
Annual Conference of the International-Society-on-Oxygen-Transport-to-Tissue
Available from: 2009-05-06 Created: 2009-05-06 Last updated: 2017-12-13Bibliographically approved

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