Retention of the cyanobacterial neurotoxin beta-N-methylamino-l-alanine in melanin and neuromelanin-containing cells: a possible link between Parkinson-dementia complex and pigmentary retinopathy
2009 (English)In: Pigment cell & melanoma research, ISSN 1755-1471, Vol. 22, no 1, 120-130 p.Article in journal (Refereed) Published
beta-N-methylamino-l-alanine (BMAA), a neurotoxic amino acid produced by cyanobacteria, has been suggested to be involved in the etiology of a neurodegenerative disease complex which includes Parkinson-dementia complex (PDC). In PDC, neuromelanin-containing neurons in substantia nigra are degenerated. Many PDC patients also have an uncommon pigmentary retinopathy. The aim of this study was to investigate the distribution of (3)H-BMAA in mice and frogs, with emphasis on pigment-containing tissues. Using autoradiography, a distinct retention of (3)H-BMAA was observed in melanin-containing tissues such as the eye and neuromelanin-containing neurons in frog brain. Analysis of the binding of (3)H-BMAA to Sepia melanin in vitro demonstrated two apparent binding sites. In vitro-studies with synthetic melanin revealed a stronger interaction of (3)H-BMAA with melanin during synthesis than the binding to preformed melanin. Long-term exposure to BMAA may lead to bioaccumulation in melanin- and neuromelanin-containing cells causing high intracellular levels, and potentially changed melanin characteristics via incorporation of BMAA into the melanin polymer. Interaction of BMAA with melanin may be a possible link between PDC and pigmentary retinopathy.
Place, publisher, year, edition, pages
2009. Vol. 22, no 1, 120-130 p.
BMAA, neuromelanin, melanin, frog, Parkinson, ALS/PDC
IdentifiersURN: urn:nbn:se:uu:diva-102429DOI: 10.1111/j.1755-148X.2008.00508.xISI: 000262513500016PubMedID: 19154235OAI: oai:DiVA.org:uu-102429DiVA: diva2:216135