uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Economic evaluation of proton radiation therapy in the treatment of breast cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Show others and affiliations
2005 (English)In: Radiotherapy and Oncology, ISSN 0167-8140, Vol. 75, no 2, 179-85 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: Proton beam therapy offers potential clinical advantages compared with conventional radiation therapy for many cancer patients. The benefits are mainly a result of a more favourable dose distribution. The treatment cost with proton radiation is higher than for conventional radiation, mainly due to the large investment cost of building a proton therapy facility. It is therefore important to evaluate whether the medical benefits of proton therapy are large enough to justify the higher treatment costs, compared with conventional radiation therapy. PATIENTS AND METHODS: The cost-effectiveness of proton therapy in the treatment of 55-year old women with left-sided breast cancer was assessed. A Markov cohort simulation model was used to simulate the life of patients diagnosed with breast cancers and treated with radiation. Cost and quality adjusted life years (QALYs) were the primary outcome measures. RESULTS: The study found a cost per QALY gained of 67,000 Euro for the base case analysis of an average breast cancer patient. The cost per QALY gained would, however, be considerably lower if a population with high-risk of developing cardiac disease was treated. Sensitivity analyses showed that the results were stable and that the risk of cardiac disease was the most important parameter. CONCLUSIONS: The results indicate that proton therapy for breast cancer can be cost-effective if appropriate risk groups are chosen as targets for the therapy.

Place, publisher, year, edition, pages
2005. Vol. 75, no 2, 179-85 p.
Keyword [en]
Breast cancer, Proton radiation, Cost, Sweden, Cardiac disease
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-102494DOI: 10.1016/j.radonc.2005.03.006PubMedID: 15885828OAI: oai:DiVA.org:uu-102494DiVA: diva2:216265
Available from: 2009-05-07 Created: 2009-05-07 Last updated: 2009-05-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Oncology, Radiology and Clinical Immunology
In the same journal
Radiotherapy and Oncology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 176 hits
ReferencesLink to record
Permanent link

Direct link