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Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
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2009 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 116, no 3, 363-370 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate possible interactions between the gene coding for activating protein-2 beta (AP-2 beta) and psychosocial factors to predict depressive symptoms in adolescents. Two-hundred 16- and 19-year-old adolescents from the county of Västmanland, Sweden, were asked to complete a questionnaire, interviewed about psychosocial risk factors, and genotyped with regard to the transcription factor AP-2 beta intron 2 polymorphism. AP-2 beta genotype interacted significantly both with type of housing and parental separation to predict depressive symptoms. Individuals who were homozygous for the short AP-2 beta allele displayed higher depression scores when psychosocial adversity was taken into account. Amongst carriers of one or two copies of the long allele, there was no difference in depressive symptoms despite differences in psychosocial environments.

Place, publisher, year, edition, pages
2009. Vol. 116, no 3, 363-370 p.
Keyword [en]
Depression, Adolescent, Gene, Environment, Transcription factor AP-2
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-102678DOI: 10.1007/s00702-009-0183-3ISI: 000263897900013PubMedID: 19184334OAI: oai:DiVA.org:uu-102678DiVA: diva2:216614
Available from: 2009-05-11 Created: 2009-05-11 Last updated: 2010-08-25Bibliographically approved

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Centre for Clinical Research, County of VästmanlandDepartment of Neuroscience
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Journal of neural transmission
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