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Circulating immune complexes of A beta and IgM in plasma of patients with Alzheimer's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
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2009 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 116, no 7, 913-920 p.Article in journal (Refereed) Published
Abstract [en]

It has previously been shown that immune complexes (IC) of a given biomarker with class M immunoglobulins (IgM) provide better performances compared to the unbound biomarker in a number of cancer entities. In the present work, we investigated IC of IgM-Abeta as a potential biomarker for Alzheimer's disease (AD). Abeta-IgM concentration has been measured in 75 plasma samples from patients with AD, individuals with mild cognitive impairment (MCI), and healthy age- and sex-matched controls (HC). To characterize the fractions associated with Abeta, pooled plasma samples were subjected to gel-filtration analysis. Size-separated fractions were analyzed for the presence of Abeta using a sandwich ELISA assay. A strong reactivity was observed in the high molecular weight IgM (>500 kDa) and 150 kDa (IgG) fractions indicating that blood Abeta is strongly associated with antibodies. Using an ELISA assay detecting Abeta-IgM complexes, we observed that high levels of Abeta-IgMs were detectable in HC and MCI patients; however, there was no significant difference to the AD group.

Place, publisher, year, edition, pages
2009. Vol. 116, no 7, 913-920 p.
Keyword [en]
Alzheimer's disease, Immune complexes, A beta, Biomarkers, Plasma
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-102707DOI: 10.1007/s00702-009-0224-yISI: 000267341300016PubMedID: 19415450OAI: oai:DiVA.org:uu-102707DiVA: diva2:216616
Available from: 2009-05-11 Created: 2009-05-11 Last updated: 2010-11-01Bibliographically approved

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