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Monoallelic expression of MAOA in skin fibroblasts
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
2006 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 348, no 2, 763-767 p.Article in journal (Refereed) Published
Abstract [en]

X chromosome inactivation in mammalian females occurs early in embryonic development and renders most genes on the inactive X chromosome transcriptionally silenced. As a consequence, females will display an X chromosomal parent-of-origin mosaiscism with regard to which parental allele that is expressed. Some genes, however, escape inactivation and will therefore be expressed from both alleles. In this study, we have investigated if the X-linked MAO-A gene has bi- or mono-allelic expression. This information would indicate whether or not MAO-A gene dosage could potentially explain the observed gender differences that show functional connections to the serotonin system, such as aggression, and impulsiveness. To investigate the X inactivation status of MAO-A we have used primary clonal cell cultures, on which allelic expression was assessed with RFLP analysis. Our results show that the MAO-A gene has mono-allelic expression in these cells. This could have important implications for understanding traits that display gender differences.

Place, publisher, year, edition, pages
2006. Vol. 348, no 2, 763-767 p.
National Category
Medical and Health Sciences Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-102698DOI: 10.1016/j.bbrc.2006.07.131ISI: 000240275000061PubMedID: 16890910OAI: oai:DiVA.org:uu-102698DiVA: diva2:216672
Available from: 2009-05-11 Created: 2009-05-11 Last updated: 2017-12-13Bibliographically approved

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