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Aggressive behavior linked to corticotropin-reactive autoantibodies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
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2006 (English)In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 60, no 8, 799-802 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Altered stress response is characteristic for subjects with abnormal aggressive and antisocial behavior, but the underlying biological mechanisms are unclear. We hypothesized that autoantibodies (autoAbs) directed against several stress-related neurohormones may exist in aggressive subjects. METHODS: Using enzyme-linked immunosorbent assay, we studied whether autoAbs directed against corticotropin (ACTH), alpha-melanocyte-stimulating hormone (alpha-MSH), oxytocin, and vasopressin are present in serum of male subjects with conduct disorder and prisoners with history of violence. Healthy blood donors served as control subjects. RESULTS: Both conduct disorder and prisoners groups displayed strongly increased levels of ACTH-reactive immunoglobulin G (IgG) and immunoglobulin M (IgM) autoAbs compared with control subjects. Levels of oxytocin-reactive IgM autoAbs were slightly increased in both groups of aggressive subjects, whereas levels of vasopressin-reactive IgG and IgM autoAbs were lower only in conduct disorder. No differences in the levels of alpha-MSH-reactive autoAbs were found between aggressive and control subjects. CONCLUSIONS: High levels of ACTH-reactive autoAbs as well as altered levels of oxytocin- and vasopressin-reactive autoAbs found in aggressive subjects may interfere with the neuroendocrine mechanisms of stress and motivated behavior. Our data suggest a new biological mechanism of human aggressive behavior that involves autoAbs directed against several stress-related neurohormones.

Place, publisher, year, edition, pages
2006. Vol. 60, no 8, 799-802 p.
Keyword [en]
Autoimmunity, conduct disorder, neuropeptides, stress, neuroendocrinology, neuropsychoimmunology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-102699DOI: 10.1016/j.biopsych.2006.03.081ISI: 000241264100004PubMedID: 16876133OAI: oai:DiVA.org:uu-102699DiVA: diva2:216674
Available from: 2009-05-11 Created: 2009-05-11 Last updated: 2010-10-05Bibliographically approved

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