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Platelet MAO-B, personality, and psychopathology
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
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2005 (English)In: Journal of Abnormal Psychology, ISSN 0021-843X, E-ISSN 1939-1846, Vol. 114, no 3, 477-482 p.Article in journal (Refereed) Published
Abstract [en]

The article investigates the relationships between platelet monoamine oxidase-B (MAO-B) activity, personality, and psychopathology (Diagnostic and Statistical Manual of Mental Disorders [4th ed.; American Psychiatric Association, 1994] diagnoses. These relationships were assessed in 178 incarcerated male juvenile delinquents. Even after controlling for smoking, the authors found that both Internalizing and Externalizing Psychopathology were negatively related to MAO-B activity. In the final reduced model, novelty seeking fully mediated the relationships between MAO-B and Externalizing Psychopathology but not between MAO-B and Internalizing Psychopathology. It was hypothesized that low platelet MAO-B activity does not directly predispose individuals to psychopathology but is related to specific personality traits, which in turn represent a vulnerability factor for psychopathology. Future studies should help clarify the nature of the relationships between personality, biological markers, and psychopathology.

Place, publisher, year, edition, pages
2005. Vol. 114, no 3, 477-482 p.
Keyword [en]
juvenile delinquents, platelet MAO-B, psychopathology, personality, novelty seeking
National Category
Medical and Health Sciences Psychology
URN: urn:nbn:se:uu:diva-102703DOI: 10.1037/0021-843X.114.3.477ISI: 000231455000015PubMedID: 16117585OAI: oai:DiVA.org:uu-102703DiVA: diva2:216678
Available from: 2009-05-11 Created: 2009-05-11 Last updated: 2016-02-17Bibliographically approved

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Ruchkin, Vladislav V
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