uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Regulation of autoimmune encephalomyelitis by toll-like receptors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Lobell / Autoimmuna sjukdomar, Autoimmunity)
2009 (English)In: Autoimmunity Reviews, ISSN 1568-9972, E-ISSN 1873-0183, Vol. 8, no 6, 506-509 p.Article in journal (Refereed) Published
Abstract [en]

Experimental autoimmune encephalomyelitis (EAE) is a Th17-mediated autoimmune disease and an animal model for multiple sclerosis (MS). Complete Freund's adjuvant (CFA) contains pathogen-associated molecular patterns (PAMPs) that bind toll-like receptors (TLRs), and is necessary to induce EAE. Upstream TLR signals modify innate and adaptive immune responses in EAE. In detail, the common TLR adaptor molecule MyD88 is necessary for induction of EAE, and mediates activation of peripheral myeloid dendritic cells (mDCs) and differentiation of autoimmune Th17 cells. The stimulatory TLRs have not yet been identified for Th17 cells. TLR4 down regulates disease severity in EAE and Th17 cell responses, but promotes Th1 cell responses, which may inhibit the differentiation of Th17 cells. Moreover, treatment with a TLR4 ligand tolerizes mice and prevents EAE. TLR9 down regulates disease severity in myelin oligodendrocyte glycoprotein (MOG)-induced EAE, whereas it promotes disease in MOG(35-55)-induced EAE. Thus MyD88, TLR4 and TLR9 modify the disease process in EAE. Both endogenous and CFA-derived TLR ligands are implicated to modulate the disease process.

Place, publisher, year, edition, pages
2009. Vol. 8, no 6, 506-509 p.
Keyword [en]
central nervous system, b-cells, multiple-sclerosis, innate immunity
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-102744DOI: 10.1016/j.autrev.2009.01.006ISI: 000266683100013PubMedID: 19211042ISBN: 1873-0183 (Electronic)OAI: oai:DiVA.org:uu-102744DiVA: diva2:216785
Available from: 2009-05-12 Created: 2009-05-11 Last updated: 2011-11-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lobell, Anna
By organisation
Department of Medical Sciences
In the same journal
Autoimmunity Reviews
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 146 hits
ReferencesLink to record
Permanent link

Direct link