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Prevalence of symptoms associated with polycystic ovary syndrome
Dept. of Obstetrics and Gynecol, Sunderby Hospital, Luleå, Sweden.
Dept. of Obstetrics and Gynecol, Sunderby Hospital, Luleå, Sweden.
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2008 (English)In: International Journal of Gynecology & Obstetrics, ISSN 0020-7292, Vol. 102, no 1, 39-43 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To establish the prevalence of symptoms associated with polycystic ovary syndrome (PCOS) in a population-based sample of women from Northern Sweden, and to relate symptoms of PCOS to features of metabolic syndrome. METHODS: A population-based survey of 147 women under 40 years of age sampled from 267 eligible women from the Northern Sweden component of the World Health Organization's MONICA study. The study involved questionnaires, physical examination, and assays of testosterone and sex hormone-binding globulin. RESULTS: The estimated prevalence of symptoms associated with PCOS was 4.8% in the study population. Features of metabolic syndrome were more common in women with signs of hyperandrogenism than in healthy controls. CONCLUSION: The estimated prevalence of PCOS in Northern Sweden corresponds with other prevalence studies. A simple questionnaire and analysis of the free androgen index are sufficient to detect the subgroup with the highest risk for metabolic syndrome.

Place, publisher, year, edition, pages
2008. Vol. 102, no 1, 39-43 p.
Keyword [en]
metabolic syndrome, obesity, polycystic ovary syndrome, Sweden
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-102819DOI: 10.1016/j.ijgo.2008.01.023ISI: 000257613500009PubMedID: 18321516OAI: oai:DiVA.org:uu-102819DiVA: diva2:216799
Available from: 2009-05-12 Created: 2009-05-12 Last updated: 2010-03-10Bibliographically approved
In thesis
1. Metabolic Aspects in the Polycystic Ovary Syndrome
Open this publication in new window or tab >>Metabolic Aspects in the Polycystic Ovary Syndrome
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of childbearing age and is associated with a number of metabolic disturbances. It has been hypothesised these women carry an increased risk of developing cardiovascular diseases (CVD) with advancing age.

The first aim of this thesis was to establish the prevalence of PCOS-related symptoms in Northern Sweden. The Northern part of the WHO MONICA project was used for this purpose. Based on self-reported menstrual disturbances and hirsutism together with biochemical analyses of free androgen index, the estimated prevalence of PCOS in Northern Sweden was 4.8%, which corresponded with previous prevalence studies.

Disturbances in the fibrinolytic system are predictors of future cardiovascular events and measurements of plasminogen activator inhibitor 1 (PAI-1) activity and tissue plasminogen activator (tPA) mass concentration may be used to assess fibrinolytic activity in women with PCOS. From the findings, over-weight women with PCOS had impaired fibrinolysis, especially if they displayed objective biochemical markers of hyperandrogenism. Conversely, lean women with PCOS, displayed no signs of disturbed fibrinolysis.

The adipose tissue is an active endocrine organ that produces and releases hormones, pro- and anti-inflammatory cytokines, and chemoattractant cytokines. Proinflammatory molecules produced by adipose tissue can be active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. The findings suggested being overweight, rather than the PCOS diagnosis per se, was the main explanatory variable for elevated adipose tissue inflammation in PCOS patients.

Weight reduction is the primary target for intervention in overweight and obese women with PCOS. When this thesis was planned, no placebo-controlled trials on anti-obesity drugs in women with PCOS had been conducted. Sibutramine in combination with lifestyle intervention resulted in significant weight reduction in overweight women with PCOS. In addition to the weight loss, sibutramine appeared to have a beneficial effect on metabolic and cardiovascular risk factors.






Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2010. 65 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 534
PCOS, prevalence, fibrinolysis, inflammatory markers, over weight
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
urn:nbn:se:uu:diva-120235 (URN)978-91-554-7746-2 (ISBN)
Public defence
2010-04-23, Konferenscentrum, Sunderby sjukhus, Luleå, 12:00 (Swedish)
Available from: 2010-04-01 Created: 2010-03-10 Last updated: 2010-04-01Bibliographically approved

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