The Auger effect in molecular targeting therapy.
2008 (English)In: Targeted radionuclide tumor therapy., Springer , 2008, 195-214 p.Chapter in book (Other academic)
Knowledge on the physical and biological aspects of Auger-electron emission is described and the major attempts to use such emitters in cancer therapy are discussed. Focus is on the need for nuclear localization of the Auger-electron emitters, i.e. preferably targeting the nuclear DNA, to have a good therapy effect. Delivery of Auger-electron emitters using nucleoside analogues, DNA-intercalators, minor groove binders, hormone receptor ligands and oligonucleotides are described as well as the need for nuclear localization signals in peptides and proteins.
Place, publisher, year, edition, pages
Springer , 2008. 195-214 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-102930DOI: 10.1007/978-1-4020-8696-0_11ISBN: 978-1-4020-8695-3OAI: oai:DiVA.org:uu-102930DiVA: diva2:217053