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The Auger effect in molecular targeting therapy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
2008 (English)In: Targeted radionuclide tumor therapy., Springer , 2008, 195-214 p.Chapter in book (Other academic)
Abstract [en]

Knowledge on the physical and biological aspects of Auger-electron emission is described and the major attempts to use such emitters in cancer therapy are discussed. Focus is on the need for nuclear localization of the Auger-electron emitters, i.e. preferably targeting the nuclear DNA, to have a good therapy effect. Delivery of Auger-electron emitters using nucleoside analogues, DNA-intercalators, minor groove binders, hormone receptor ligands and oligonucleotides are described as well as the need for nuclear localization signals in peptides and proteins.

Place, publisher, year, edition, pages
Springer , 2008. 195-214 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-102930DOI: 10.1007/978-1-4020-8696-0_11ISBN: 978-1-4020-8695-3 (print)OAI: oai:DiVA.org:uu-102930DiVA: diva2:217053
Available from: 2009-05-12 Created: 2009-05-12 Last updated: 2009-11-11Bibliographically approved

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