Fast, acid-free, and selective lactamization of lactones in ionic liquids
2008 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 73, no 21, 8627-30 p.Article in journal (Refereed) Published
A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Brønsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.
Place, publisher, year, edition, pages
2008. Vol. 73, no 21, 8627-30 p.
IdentifiersURN: urn:nbn:se:uu:diva-102940DOI: 10.1021/jo8015264ISI: 000260533300073PubMedID: 18826282OAI: oai:DiVA.org:uu-102940DiVA: diva2:217087