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Fast, acid-free, and selective lactamization of lactones in ionic liquids
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
2008 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 73, no 21, 8627-30 p.Article in journal (Refereed) Published
Abstract [en]

A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Brønsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.

Place, publisher, year, edition, pages
2008. Vol. 73, no 21, 8627-30 p.
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Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-102940DOI: 10.1021/jo8015264ISI: 000260533300073PubMedID: 18826282OAI: oai:DiVA.org:uu-102940DiVA: diva2:217087
Available from: 2009-05-13 Created: 2009-05-13 Last updated: 2013-07-04Bibliographically approved

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Larhed, Mats

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