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Extracellular clusterin promotes neuronal network complexity in vitro
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2008 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 19, no 15, 1487-1491 p.Article in journal (Refereed) Published
Abstract [en]

Clusterin (apolipoprotein J), a highly conserved amphiphatic glycoprotein and chaperone, has been implicated in a wide range of physiological and pathological processes. As a secreted protein, clusterin has been shown to act extracellularly where it is involved in lipid transportation and clearance of cellular debris. Intracellularly, clusterin may regulate signal transduction and is upregulated after cell stress. After neural injury, clusterin may be involved in nerve cell survival and postinjury neuroplasticity. In this study, we investigated the role of extracelullar clusterin on neuronal network complexity in vitro. Quantitative analysis of clustrin-treated neuronal cultures showed significantly higher network complexity. These findings suggest that in addition to previously demonstrated neuroprotective roles, clusterin may also be involved in neuronal process formation, elongation, and plasticity.

Place, publisher, year, edition, pages
2008. Vol. 19, no 15, 1487-1491 p.
Keyword [en]
apolipoprotein, complexity, fractal analysis, neuronal cultures
National Category
Medical and Health Sciences Neurosciences
Research subject
Neuroscience
Identifiers
URN: urn:nbn:se:uu:diva-103044DOI: 10.1097/WNR.0b013e32830fe4d1ISI: 000259728400009OAI: oai:DiVA.org:uu-103044DiVA: diva2:217294
Available from: 2009-05-13 Created: 2009-05-13 Last updated: 2017-12-13Bibliographically approved

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NeuroanatomyDevelopmental GeneticsDepartment of Medical Biochemistry and Microbiology
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